Chemical shift assignments of wildtype human leptin.

Xiao Fan, Ruiqi Qin, Wensu Yuan, Jing-Song Fan, Zhi Lin

Biomolecular NMR assignments 2023 Dec

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Leptin is an adipose tissue-expressed 16-kDa hormone encoded by the ob/ob gene. It serves a crucial role in regulating diverse physiological processes, including body weight control, energy homeostasis regulation, promotion of cell proliferation, and more. Emerging research has also revealed potential implications of leptin in various aging-related diseases, suggesting multifaceted physiological roles of leptin. Structural investigation of wild-type leptin in apo form is of particular importance to understand its conformational plasticity for receptor interaction and recognition. Here, we report backbone and side-chain resonance assignments of wild-type human leptin as a basis for structural and functional studies on leptin-mediated signaling. © 2023. The Author(s), under exclusive licence to Springer Nature B.V.

Citation

Xiao Fan, Ruiqi Qin, Wensu Yuan, Jing-Song Fan, Zhi Lin. Chemical shift assignments of wildtype human leptin. Biomolecular NMR assignments. 2023 Dec;17(2):265-268