The possibilities of LOXL4 as a prognostic marker for carcinomas.

Lysyl oxidase-like 4 (LOXL4), a member of lysyl oxidase family, is a copper and lysine tyrosylquinone-dependent amine oxidase that serves the role of catalyzing the cross-linking of elastin and collagen in the extracellular matrix. Numerous studies have shown a significant association between LOXL4 expression levels and tumor proliferation, migration, invasion and patients' prognosis and overall survival in different types of tumors. Here we review their relationship and the molecular pathogenesis behind them, aiming to explore the possibilities of LOXL4 as a prognostic marker for diverse carcinomas and provide some indications for further research in this field. © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

Citation

Jiaming Wang, Chaojian Chen, Jiayi Huang, Ziman Xie, Xiaoxue Chen, Ziqi Zheng, Enmin Li, Haiying Zou. The possibilities of LOXL4 as a prognostic marker for carcinomas. Amino acids. 2023 Nov;55(11):1519-1529

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PMID: 37814029

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