Polyamines and hormesis: Making sense of a dose response dichotomy.

Edward Calabrese, A Wallace Hayes, Peter Pressman, Rachna Kapoor, Gaurav Dhawan, Vittorio Calabrese, Evgenios Agathokleous

Chemico-biological interactions 2023 Dec 01

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The diverse biological effects of polyamines (putrescine, spermidine and spermine) were reviewed in the context of hormesis in an integrative manner for the first time. The findings illustrate that each of these polyamines commonly induces hormetic dose responses in a wide range of biological models and types of cells for multiple endpoints in numerous plant species and animal models. Plant research emphasized preconditioning experimental studies in which the respective polyamines conferred some protection against the damaging effects of a broad range of environmental stressors such as drought, salinity, cold/heat, heavy metals and UV-damage in an hormetic manner. Polyamine-based animal hormesis studies emphasized biomedical endpoints such as longevity and neuroprotection. These findings have important biological and biomedical implications and should guide experimental designs of low dose investigations. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Edward Calabrese, A Wallace Hayes, Peter Pressman, Rachna Kapoor, Gaurav Dhawan, Vittorio Calabrese, Evgenios Agathokleous. Polyamines and hormesis: Making sense of a dose response dichotomy. Chemico-biological interactions. 2023 Dec 01;386:110748