Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types.

In the lungs, the cystic fibrosis transmembrane conductance regulator (CFTR) regulates ion transport in surface-airway epithelia and submucosal glands, thus determining airway surface liquid (ASL) volume and mucus hydration. In this issue of the JCI, Lei Lei and colleagues report that the CFTR-rich and barttin/Cl- channel-expressing ionocytes mediate chloride absorption across airway epithelia, whereas the more abundant basal cells and secretory cells mediate chloride secretion. Thus, CFTR-mediated secretion and absorption of chloride ions in the lung are segregated by cell type, which has implications for future molecular therapies for cystic fibrosis lung disease.

Citation

Burkhard Tümmler. Puzzle resolved: CFTR mediates chloride homeostasis by segregating absorption and secretion to different cell types. The Journal of clinical investigation. 2023 Oct 16;133(20)

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PMID: 37843282

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