Modulation of monocyte subtypes in diabetes after non-surgical periodontal treatment.

The current study aims to evaluate the effect of non-surgical periodontal treatment on the modulation of monocyte phenotype, in the presence or absence of diabetes. The identification, quantification, and phenotypic characterization of monocyte subtypes (classical, intermediate, and non-classical) were performed by flow cytometry, at baseline and 1 month after the end of non-surgical periodontal treatment, in patients with periodontitis, associated or not with diabetes. There was an increase in non-classical monocytes after treatment and a reduction in intermediate monocytes, without differences for the classical subtype, regardless of the diabetes status. Furthermore, there was a reduction in intermediate monocytes and an increase in non-classical and classical monocytes after treatment in the diabetes group, while no significant differences were observed for classical, intermediate, and non-classical monocytes in the group without diabetes. Comparisons between the two groups showed significant differences for classical, intermediate, and non-classical monocytes at baseline; these differences were not found one month after treatment. Non-surgical periodontal treatment leads to modulation of monocytes to a less inflammatory phenotype, especially in individuals with diabetes. A better understanding of the role of these biomarkers in the periodontitis contex may constitute a new strategic target for a better treatment of patiens with diabetes associated to periodontitis. Brazilian Registry of Clinical Trials-RBR-35szwc. Jhefferson Miranda Alves and Danielle Borges Germano contributed equality to this study and should be considered first authors. © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Citation

Jhefferson Miranda Alves, Danielle Borges Germano, Yeon Jung Kim, Francisco Antonio Helfenstein Fonseca, Maria Cristina Izar, Izabela Dorota Tuleta, Rogério Nagai, Neil Ferreira Novo, Yára Juliano, Lucas Melo Neves, Débora Pallos, Carolina Nunes França. Modulation of monocyte subtypes in diabetes after non-surgical periodontal treatment. Clinical oral investigations. 2023 Nov;27(11):6847-6854

Mesh Tags

Substances

PMID: 37843636

search → result