Effects of Gabapentin on Postoperative Pain and Opioid Consumption Following Laparoscopic Cholecystectomy: A Systematic Review and Meta-analysis.

Examine the efficacy of gabapentin on postoperative pain scores and opioid consumption in laparoscopic cholecystectomy. Systematic review and meta-analysis. PubMed, EBSCO, CINAHL, the Cochrane Central Register of Controlled Trials, Google Scholar, and gray literature was used to search the literature. Only randomized controlled trials were included. Outcomes were reported using the risk ratio and mean difference (MD). Risk of bias and the grades of recommendation, assessment, development, and evaluation (GRADE) system was used to the assessed quality of evidence. Nineteen trials involving 2,068 patients were analyzed. Compared to placebo, gabapentin reduced the cumulative pain scores in the first 24 hours after surgery (MD, -1.19; 95% CI, -1.39-0.99; P < .00011), opioid consumption (MD, -3.51; 95% CI, -4.67 to -2.35; P < .00001), and the incidence of postoperative nausea and vomiting (risk ratio, 0.64; 95% CI, 0.52-0.78; P < .00001) with prolonged time to first analgesic rescue (MD, 210.9; 95% CI, 76.90-344.91; P = .002). However, gabapentin has little to no effect on the incidence of sedation, somnolence, and respiratory depression. Gabapentin can be added as part of the multimodal pain management for patients undergoing laparoscopic cholecystectomy. Extrapolation of these findings to clinical settings must take into consideration the limitations identified in this review. Copyright © 2023 The American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.

Citation

Katherine A Froehlich, Zeus G Deleon, Tito D Tubog. Effects of Gabapentin on Postoperative Pain and Opioid Consumption Following Laparoscopic Cholecystectomy: A Systematic Review and Meta-analysis. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses. 2024 Feb;39(1):132-141

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PMID: 37855760

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