Correlation Engine 2.0
Clear Search sequence regions

  • adult (1)
  • and disease (1)
  • cancers (2)
  • gender (1)
  • men (2)
  • never drink (2)
  • never smoke (5)
  • oral cancers (1)
  • patients (8)
  • prognosis (1)
  • smoker (1)
  • smoking (1)
  • squamous cell carcinoma (4)
  • status (1)
  • women (4)
  • Sizes of these terms reflect their relevance to your search.

    Introduction  Oral carcinoma has been reported at a substantial proportion in patients who never smoke and never drink. However, the proportion may vary by subsite and ethnicity. Objective  We aimed to determine the clinicopathological features of buccal squamous cell carcinoma (SCC) in a Japanese population. Methods  We retrospectively analyzed the records of patients diagnosed with buccal SCC at our institution from September 2002 to November 2015. We reviewed the gender, age, tumor status, treatment, smoking, alcohol drinking, multiple primary cancers, and prognosis of the patients. The overall and cause-specific survival rates were calculated, and the effects of clinicopathological variables were assessed by univariate analysis. Furthermore, the cause of death was evaluated. Results  Among the 63 patients (men: 38; women: 25) included in the present study, 29 (46.0%) never smoked or drank. Women were almost 5 years older than men ( p  = 0.014). The number of women in the group who never smoked or drank was disproportionately higher than that of those in the smoker or drinker groups ( p  < 0.001). In total, 29 patients (46.0%) had 59 multiple primary cancers, including 26 oral cancers. Surgeries and radiotherapy were performed in 57 (90.5%) and 6 (9.5%) cases, respectively. The 5-year overall survival and disease-specific survival rates were 74.6 and 78.8%, respectively. Conclusion  Our study confirms that buccal SCC may develop in older adult Japanese patients, especially in women who have never smoked or drank. These patients could be at risk for second primary malignancy. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( ).


    Yoshiyuki Iida, Shinichi Okada, Yuki Irifune, Seiya Goto, Kotaro Ishida, Fuyuki Sato, Takashi Yurikusa, Koiku Asakura, Ayaka Tsuzuki, Takashi Mukaigawa. Clinicopathological Features of Buccal Squamous Cell Carcinoma with Focus on Patients Who Never Smoke and Never Drink. International archives of otorhinolaryngology. 2023 Oct;27(4):e551-e558

    PMID: 37876683

    View Full Text