Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection.

Mitochondrial antiviral signaling protein (MAVS) and stimulator of interferon (IFN) genes (STING) are key adaptor proteins required for innate immune responses to RNA and DNA virus infection. Here, we show that zebrafish transmembrane protein 47 (TMEM47) plays a critical role in regulating MAVS- and STING-triggered IFN production in a negative feedback manner. TMEM47 interacted with MAVS and STING for autophagic degradation, and ATG5 was essential for this process. These findings suggest the inhibitory function of TMEM47 on MAVS- and STING-mediated signaling responses during RNA and DNA virus infection.

Citation

Long-Feng Lu, Zhuo-Cong Li, Can Zhang, Dan-Dan Chen, Ke-Jia Han, Xiao-Yu Zhou, Xue-Li Wang, Xi-Yin Li, Li Zhou, Shun Li. Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection. Journal of virology. 2023 Nov 30;97(11):e0143423

Mesh Tags

Substances

PMID: 37882518

search → result