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    The availability of nutrients to microorganisms varies considerably between different environments, and changes can occur rapidly. As a general rule, a fast growth rate-typically growth on glucose-is associated with the repression of other carbohydrate utilization genes, but it is not clear to what extent catabolite repression is exerted by other sugars. We investigated the hierarchy of sugar utilization after substrate transitions in Lactococcus cremoris. For this, we determined the proteome and carbohydrate utilization capacity after growth on different sugars. The results show that the preparedness of cells for the utilization of "slower" sugars is not strictly determined by the growth rate. The data point to individual proteins relevant for various sugar transitions and suggest that the evolutionary history of the organism might be responsible for deviations from a strictly growth rate-related sugar catabolization hierarchy.

    Citation

    Sieze Douwenga, Berdien van Olst, Sjef Boeren, Yanzhang Luo, Xin Lai, Bas Teusink, Jacques Vervoort, Michiel Kleerebezem, Herwig Bachmann. The hierarchy of sugar catabolization in Lactococcus cremoris. Microbiology spectrum. 2023 Dec 12;11(6):e0224823

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    PMID: 37888986

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