Na+ Binding and Transport: Insights from Light-Driven Na+-Pumping Rhodopsin.

Na+ plays a vital role in numerous physiological processes across humans and animals, necessitating a comprehensive understanding of Na+ transmembrane transport. Among the various Na+ pumps and channels, light-driven Na+-pumping rhodopsin (NaR) has emerged as a noteworthy model in this field. This review offers a concise overview of the structural and functional studies conducted on NaR, encompassing ground/intermediate-state structures and photocycle kinetics. The primary focus lies in addressing key inquiries: (1) unraveling the translocation pathway of Na+; (2) examining the role of structural changes within the photocycle, particularly in the O state, in facilitating Na+ transport; and (3) investigating the timing of Na+ uptake/release. By delving into these unresolved issues and existing debates, this review aims to shed light on the future direction of Na+ pump research.

Citation

Qifan Yang, Deliang Chen. Na+ Binding and Transport: Insights from Light-Driven Na+-Pumping Rhodopsin. Molecules (Basel, Switzerland). 2023 Oct 17;28(20)

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PMID: 37894614

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