The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy.

Lanxia Meng, Congcong Liu, Miao Liu, Jiehui Chen, Chaoyang Liu, Zhaohui Zhang, Guiqin Chen, Zhentao Zhang

Cell reports 2023 Nov 28

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The molecular mechanisms that trigger Tau aggregation in Alzheimer's disease (AD) remain elusive. Fungi, especially Saccharomyces cerevisiae (S. cerevisiae), can be found in brain samples from patients with AD. Here, we show that the yeast protein Ure2p from S. cerevisiae interacts with Tau and facilitates its aggregation. The Ure2p-seeded Tau fibrils are more potent in seeding Tau and causing neurotoxicity in vitro. When injected into the hippocampus of Tau P301S transgenic mice, the Ure2p-seeded Tau fibrils show enhanced seeding activity compared with pure Tau fibrils. Strikingly, intracranial injection of Ure2p fibrils promotes the aggregation of Tau and cognitive impairment in Tau P301S mice. Furthermore, intranasal infection of S. cerevisiae in the nasal cavity of Tau P301S mice accelerates the aggregation of Tau. Together, these observations indicate that the yeast protein Ure2p initiates Tau pathology. Our results provide a conceptual advance that non-mammalian prions may cross-seed mammalian prion-like proteins. Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Citation

Lanxia Meng, Congcong Liu, Miao Liu, Jiehui Chen, Chaoyang Liu, Zhaohui Zhang, Guiqin Chen, Zhentao Zhang. The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy. Cell reports. 2023 Nov 28;42(11):113342