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Our results indicate that most severe acute respiratory syndrome coronavirus 2 genomes sampled from patients had a mutation rate ≤1.07 ‰ and genome-tail proteins (including S protein) were the main sources of genetic polymorphism. The analysis of the virus-host interaction network of genome-tail proteins showed that they shared some antiviral signaling pathways, especially the intracellular protein transport pathway.

Citation

Heng Li, Liping Ding, Rui Liao, Nini Li, Xiaoping Hong, Zhenyou Jiang, Dongzhou Liu. Global genomic diversity and conservation of SARS-CoV-2 since the COVID-19 outbreak. Microbiology spectrum. 2023 Dec 12;11(6):e0282623

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PMID: 37909759

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