Two highly conjugated ergosterols from the fungus Psathyrella rogueiana and their anti-inflammatory activity.

Two previously undescribed ergosterols containing a highly conjugated ring system, psathrosterols A and B (1 and 2), have been isolated from the fungus Psathyrella rogueiana. Their structures with absolute configurations were established by extensive spectroscopic methods, as well as single crystal X-ray diffraction. Compounds 1 and 2 showed inhibitory activity against NO production with IC50 values of 22.3 and 16.4 μM, respectively.

Citation

Tao Feng, Wang-Qiu Deng, Ji-Kai Liu. Two highly conjugated ergosterols from the fungus Psathyrella rogueiana and their anti-inflammatory activity. Journal of Asian natural products research. 2024 Jan;26(1):52-58

Mesh Tags

Substances

PMID: 37947812

search → result