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Mitochondrial entry gate as regulatory hub.

Fabian den Brave, Nikolaus Pfanner, Thomas Becker

Biochimica et biophysica acta. Molecular cell research 2024 Feb


filter terms:
  • biogenesis (1)
  • cellular (2)
  • cytosol (1)
  • hub protein (1)
  • import (1)
  • precursor proteins (3)
  • protein complex (2)
  • protein import (3)
  • subunits (1)
  • tom complex (2)
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    Mitochondria import 1000-1300 different precursor proteins from the cytosol. The main mitochondrial entry gate is formed by the translocase of the outer membrane (TOM complex). Molecular coupling and modification of TOM subunits control and modulate protein import in response to cellular signaling. The TOM complex functions as regulatory hub to integrate mitochondrial protein biogenesis and quality control into the cellular proteostasis network. Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

    Citation

    Fabian den Brave, Nikolaus Pfanner, Thomas Becker. Mitochondrial entry gate as regulatory hub. Biochimica et biophysica acta. Molecular cell research. 2024 Feb;1871(2):119529

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    PMID: 37951505

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