Development and Pilot of an Mpox Severity Scoring System.

Clinical severity scores facilitate comparisons to understand risk factors for severe illness. For the 2022 multinational monkeypox clade IIb virus outbreak, we developed a 7-item Mpox Severity Scoring System (MPOX-SSS) with initial variables refined by data availability and parameter correlation. Application of MPOX-SSS to the first 200 patients diagnosed with mpox revealed higher scores in those treated with tecovirimat, presenting >3 days after symptom onset, and with CD4 counts <200 cells/mm3. For individuals evaluated repeatedly, serial scores were concordant with clinical observations. The pilot MPOX-SSS demonstrated good discrimination, distinguished change over time, and identified higher scores in expected groups. © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Citation

Jason Zucker, Jacob McLean, Simian Huang, Clare DeLaurentis, Shauna Gunaratne, Kate Stoeckle, Marshall J Glesby, Timothy J Wilkin, William Fischer, Inger Damon, John T Brooks. Development and Pilot of an Mpox Severity Scoring System. The Journal of infectious diseases. 2024 Mar 26;229(Supplement_2):S229-S233

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PMID: 37956401

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