What's New in Cutaneous T-Cell Lymphoma-Associated Pruritus.

Georgia Biazus Soares, Joan Guitart, Gil Yosipovitch

American journal of clinical dermatology 2024 Jan

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Cutaneous T-cell lymphomas are a heterogenous group of lymphomas that cause various skin manifestations. Severe pruritus occurs frequently in cutaneous T-cell lymphoma and negatively impacts patients' quality of life. The pathophysiology of cutaneous T-cell lymphoma-associated itch is complex and involves various immune cells, inflammatory cytokines, and neuroimmune interactions. Treating cutaneous T-cell lymphoma pruritus can be challenging, and there have been few randomized controlled studies evaluating the use of antipruritic treatments in these patients. Systemic therapies targeting the disease have also been shown to have some antipruritic effects. Furthermore, although biologic therapy has revolutionized the treatment of other pruritic skin conditions, the use of biologics in cutaneous T-cell lymphoma remains controversial. © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Citation

Georgia Biazus Soares, Joan Guitart, Gil Yosipovitch. What's New in Cutaneous T-Cell Lymphoma-Associated Pruritus. American journal of clinical dermatology. 2024 Jan;25(1):67-77