Electrical carotid sinus nerve stimulation attenuates experimental colitis induced by acetic acid in rats.

Jefferson Ícaro Soares, Thaís Marques da Silva, Jaci Airton Castania, Ulisses Ávila Reis, Luiz Felipe Moreira Roque, Adriana Barbosa Ribeiro, Helio Cesar Salgado, Aline Barbosa Ribeiro

Life sciences 2023 Dec 15

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The carotid bodies are sensors that detect physiological signals and convey them to the central nervous system, where the stimuli are processed inducing reflexes through efferent pathways. Recent studies have demonstrated that electrical stimulation of the carotid sinus nerve (CSN) triggers the anti-inflammatory reflex under different conditions. However, whether this electrical stimulation attenuates colitis was never examined. This study aimed to evaluate if the electrical CSN stimulation attenuates the experimental colitis induced by intrarectal administration of acetic acid in rats. Electrodes were implanted around the CSN to stimulate the CSN, and a catheter was inserted into the left femoral artery to record the arterial pressure. The observation of hypotensive responses confirmed the effectiveness of the electrical CNS stimulation. This maneuver was followed by a 4 % acetic acid or saline administered intrarectally. After 24 h, colons were segmented into distal and proximal parts for macroscopy, histological and biochemical assessment. As expected, the electrical CSN stimulation was effective in decreasing arterial pressure in saline and colitis rats. Moreover, electrical CSN stimulation effectively reduced colonic tissue lesions, colitis scores, and histopathologic parameters associated with colitis. In addition, the CSN stimulation also reduced the colonic mucosa pro-inflammatory cytokine interleukin-1 beta, and increased the anti-inflammatory interleukin-10, in rats submitted to colitis. These findings indicated that electrical CSN stimulation breaks the vicious cycle of local colon inflammation in colitis, which might contribute to its better outcome. Copyright © 2023 Elsevier Inc. All rights reserved.

Citation

Jefferson Ícaro Soares, Thaís Marques da Silva, Jaci Airton Castania, Ulisses Ávila Reis, Luiz Felipe Moreira Roque, Adriana Barbosa Ribeiro, Helio Cesar Salgado, Aline Barbosa Ribeiro. Electrical carotid sinus nerve stimulation attenuates experimental colitis induced by acetic acid in rats. Life sciences. 2023 Dec 15;335:122281