An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus.

Tetsuo Kubota

International journal of molecular sciences 2023 Nov 19

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Anti-DNA antibodies are hallmark autoantibodies produced in systemic lupus erythematosus (SLE), but their pathogenetic role is not fully understood. Accumulating evidence suggests that some anti-DNA antibodies enter different types of live cells and affect the pathophysiology of SLE by stimulating or impairing these cells. Circulating neutrophils in SLE are activated by a type I interferon or other stimuli and are primed to release neutrophil extracellular traps (NETs) on additional stimulation. Anti-DNA antibodies are also involved in this process and may induce NET release. Thereafter, they bind and protect extracellular DNA in the NETs from digestion by nucleases, resulting in increased NET immunogenicity. This review discusses the pathogenetic role of anti-DNA antibodies in SLE, mainly focusing on recent progress in the two research fields concerning antibody penetration into live cells and NETosis.

Citation

Tetsuo Kubota. An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus. International journal of molecular sciences. 2023 Nov 19;24(22)