Cytokines in aqueous humor of patients with congenital cataract during delayed sequential bilateral cataract surgery.

To explore the changes of cytokines expression in aqueous humor (AH) of eyes of patients with congenital cataract (CC) who underwent delayed sequential bilateral cataract surgery (DSBCS). 28 patients with CC underwent DSBCS. AH samples were collected from each eye before surgery. The contents of cytokines in AH were detected by Luminex xMAP Technology. There was no significant difference in the expression of IL-8, IP-10, MCP-1 and PDGFAA in the AH of the first and second eyes (P = 0.35, 0.39, 0.17, respectively). The level of IL-8 in the first-eye AH was negatively correlated with age (ρ=- 0.519, P = 0.008). IP-10 and MCP-1 in the second-eye AH were negatively correlated with age (ρ=- 0.483, P = 0.009; ρ=- 0.445, P = 0.018,respectively). The first-eye surgery in patients with CC may not cause the change of cytokines in the contralateral eye. The expression of IL-8, IP-10 and MCP-1 in the AH was negatively correlated with the age of patients. The study was registered at www.chictr.org.cn on March 22, 2022 and the clinical trial number is ChiCTR2200057927. © 2023. The Author(s).

Citation

Na Hui, Lei Yu, Laiqiang Qu, Hong Yan. Cytokines in aqueous humor of patients with congenital cataract during delayed sequential bilateral cataract surgery. BMC ophthalmology. 2023 Nov 30;23(1):490

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PMID: 38031045

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