Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules active in the nucleus and minimizing off-target effects. 'Active' nuclear-directed transport and efficient translocations across nuclear pore complexes provide the most effective means of maximizing nuclear localization. Nuclear-targeting systems based on nuclear localization signal (NLS) motifs have progressed significantly since the beginning of the current millennium. Here, we offer a roadmap for understanding the basic mechanisms of nuclear import in the context of actionable therapeutic design for developing NLS-therapeutics with improved treatment efficacy.


Ritabrita Goswami, Aarohi Gupta, Olga Bednova, Gaël Coulombe, Dipika Patel, Vincent M Rotello, Jeffrey V Leyton. Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design. Chemical Society reviews. 2024 Jan 02;53(1):204-226

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 38031452

View Full Text