Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review.

Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Matyas Jelinek, Jolana Lipkova, Kamil Duris. Vagus nerve stimulation as immunomodulatory therapy for stroke: A comprehensive review. Experimental neurology. 2024 Feb;372:114628

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PMID: 38042360

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