Hexylsilane-mediated direct amidation of amino acids with a catalytic amount of 1,2,4-triazole.

Tomoya Nobuta, Nozomi Tsuchiya, Yutaka Suto, Noriyuki Yamagiwa

Organic & biomolecular chemistry 2024 Jan 24

filter terms:

In this study, we report amino acid amidation using hexylsilane and a catalytic amount of 1,2,4-triazole. The conventional protection/deprotection method for the α-amino group of amino acids is not required. The corresponding α-amino amides were obtained in moderate to good yields with low to no racemization.

Citation

Tomoya Nobuta, Nozomi Tsuchiya, Yutaka Suto, Noriyuki Yamagiwa. Hexylsilane-mediated direct amidation of amino acids with a catalytic amount of 1,2,4-triazole. Organic & biomolecular chemistry. 2024 Jan 24;22(4):703-707