Molecular clips with spatially proximal urea residues for efficient transmembrane co-transport of H+/Cl- ions.

We report the design of bis(urea) functionalized amphiphilic molecular clips viz. 1a-1e to achieve efficient transmembrane co-transport of H+/Cl- ions. The most promising molecule 1a demonstrated a low nanomolar EC50 value (6.96 nM) to co-transport H+/Cl- ions via a carrier-mediated pathway and showed selective toxicity against cancerous HeLa cells as a result.

Citation

Nyaya Prakash Pradhan, Kavthekar Rupesh Namdev, Aasheesh Srivastava. Molecular clips with spatially proximal urea residues for efficient transmembrane co-transport of H+/Cl- ions. Organic & biomolecular chemistry. 2023 Dec 20;22(1):74-79

PMID: 38051156

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