Production of pharmaceutical grade [201Tl]Thallous chloride using 30 MeV cyclotron.

Sankha Chattopadhyay, Luna Barua, D G Mahesh, Shayantani Ash, Arpit Mitra, Sujata Saha Das, Samarjit Singha, Md Neyar Alam, Madhusmita, Suprakash Roy, Prosenjit Dhang, Mukesh Jain

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2024 Feb

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Multiple patient doses of [201Tl]TlCl has been produced using electrodeposited enriched 203Tl in 30 MeV cyclotron (Cyclone-30) with 28 MeV proton energy at 50 μA beam current for 8 h. Ion Exchange Column Chromatography (IECC) and liquid-liquid extraction has been employed for semi-automated radiochemical separation and purification of produced [201Tl]TlCl. The produced [201Tl]TlCl was used in coronary artery disease (CAD) patients. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Sankha Chattopadhyay, Luna Barua, D G Mahesh, Shayantani Ash, Arpit Mitra, Sujata Saha Das, Samarjit Singha, Md Neyar Alam, Madhusmita, Suprakash Roy, Prosenjit Dhang, Mukesh Jain. Production of pharmaceutical grade [201Tl]Thallous chloride using 30 MeV cyclotron. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2024 Feb;204:111128