A review on the use of prebiotics in ulcerative colitis.

James M Kennedy, Aminda De Silva, Gemma E Walton, Glenn R Gibson

Trends in microbiology 2024 May

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The gut microbiome in the inflammatory bowel disease, ulcerative colitis (UC), is different to that of healthy controls. Patients with UC have relative reductions in abundance of Firmicutes and Bifidobacterium in the colon, and an increase in sulfate-reducing bacteria. Prebiotics are dietary substrates which are selectively metabolised by the human colonic microbiota to confer health benefits to the host. This review explores our current understanding of the potential benefits of prebiotics on various clinical, biochemical, and microbiological endpoints in UC, including new perspectives gained from recent studies in the field. This review looks to the future and highlights the need for appropriately designed trials to explore this potentially exciting new avenue for the treatment of UC. Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Citation

James M Kennedy, Aminda De Silva, Gemma E Walton, Glenn R Gibson. A review on the use of prebiotics in ulcerative colitis. Trends in microbiology. 2024 May;32(5):507-515