The Human TREX-2 Complex Interacts with Subunits of the ORC Complex.

The TREX-2 protein complex is the key complex involved in the export of mRNA from the nucleus to the cytoplasm through the nuclear pores. Previously, a joint protein complex of TREX-2 with ORC was isolated in D. melanogaster. It was shown that the interaction of TREX-2 with ORC is necessary for efficient mRNA export from the nucleus to the cytoplasm. In this work, we showed that the TREX-2-ORC joint complex is also formed in human cells. © 2023. The Author(s).

Citation

M M Kurshakova, S G Georgieva, D V Kopytova. The Human TREX-2 Complex Interacts with Subunits of the ORC Complex. Doklady. Biochemistry and biophysics. 2023 Dec;513(1):346-349

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PMID: 38066323

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