Proportional-Derivative Control of Cortisol for Treatment of PTSD.

Dafina Sopi, Sajeda Amin, Sarah Ron, Trisha Satish, Parker Carnahan

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2023 Jul

filter terms:

Mental illnesses, such as depression or post-traumatic stress disorder (PTSD), often impact an individual's physiological reaction to stress via their cortisol response. We examine the regulation of cortisol within the hypothalamic-pituitary-adrenal (HPA) axis as a dynamic biosystem. We investigate the difference between the cortisol regulation of people with PTSD and healthy controls. Additionally, we investigate models for potential therapies based on proportional-derivative (PD) control to normalize and improve the stress response of those with PTSD. Such a design may be relevant to improving the treatment of PTSD, as current medical interventions are frequently imprecise and may result in unwanted side effects. The use of a PD controller in administration of hormone therapy, in contrast, can be highly measurable and patient specific.Clinical Relevance- This paper offers an approach to treating post-traumatic stress disorder (PTSD) via stabilizing an individual's endocrinal regulation as a potential future alternative to current pharmaceutical practices.

Citation

Dafina Sopi, Sajeda Amin, Sarah Ron, Trisha Satish, Parker Carnahan. Proportional-Derivative Control of Cortisol for Treatment of PTSD. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2023 Jul;2023:1-4