Multivalency emerges as a common feature of intrinsically disordered protein interactions.

Intrinsically disordered proteins (IDPs) use their unique molecular properties and conformational plasticity to interact with cellular partners in a wide variety of biological contexts. Multivalency is an important feature of IDPs that allows for utilization of an expanded toolkit for interactions with other macromolecules and confers additional complexity to molecular recognition processes. Recent studies have offered insights into how multivalent interactions of IDPs enable responsive and sensitive regulation in the context of transcription and cellular signaling. Multivalency is also widely recognized as an important feature of IDP interactions that mediate formation of biomolecular condensates. We highlight recent examples of multivalent interactions of IDPs across diverse contexts to illustrate the breadth of biological processes that utilize multivalency in molecular interactions. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Emily L Sipko, Garrett F Chappell, Rebecca B Berlow. Multivalency emerges as a common feature of intrinsically disordered protein interactions. Current opinion in structural biology. 2024 Feb;84:102742

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PMID: 38096754

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