Potentials of ionic liquids to overcome physical and biological barriers.

Elfa Beaven, Raj Kumar, Jeong Man An, Hannia Mendoza, Sabuj Chandra Sutradhar, Wonho Choi, Mahesh Narayan, Yong-Kyu Lee, Md Nurunnabi

Advanced drug delivery reviews 2024 Jan

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Over the last decades, ionic liquids (IL) have shown great potential in non-invasive delivery starting from synthetic small molecules to biological large molecules. ILs are emerging as a particular class of drug delivery systems due to their unique physiochemical properties, simple surface modification, and functionalization. These features of IL help achieve specific design principles that are essential for a non-invasive drug delivery system. In this review, we have discussed IL and their applications in non-invasive drug delivery systems. We evaluated state-of-the-art development and advances of IL aiming to mitigate the biological and physical barriers to improve transdermal and oral delivery, summarized in this review. We also provided an overview of the various factors determining the systemic transportation of IL-based formulation. Additionally, we have emphasized how the ILs facilitate the transportation of therapeutic molecules by overcoming biological barriers. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Elfa Beaven, Raj Kumar, Jeong Man An, Hannia Mendoza, Sabuj Chandra Sutradhar, Wonho Choi, Mahesh Narayan, Yong-Kyu Lee, Md Nurunnabi. Potentials of ionic liquids to overcome physical and biological barriers. Advanced drug delivery reviews. 2024 Jan;204:115157