Tim-3 Is Not Required for Establishment of CD8+ T Cell Memory to Lymphocytic Choriomeningitis Virus.

Priyanka Manandhar, Andrea L Szymczak-Workman, Lawrence P Kane

Journal of immunology (Baltimore, Md. : 1950) 2024 Feb 01

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Tim-3 is a transmembrane protein that is best known for being highly expressed on terminally exhausted CD8+ T cells associated with chronic infection and tumors, although its expression is not limited to those settings. Tim-3 is also expressed by CD8+ T cells during acute infection and by multiple other immune cell types, including CD4+ Th1 and regulatory T cells, dendritic cells, and mast cells. In this study, we investigated the role of Tim-3 signaling on CD8+ T cell memory using a Tim-3 conditional knockout mouse model and mice lacking the signaling portion of the Tim-3 cytoplasmic domain. Together, our results indicate that Tim-3 has at most a modest effect on the formation and function of CD8+ memory T cells. Copyright © 2024 by The American Association of Immunologists, Inc.

Citation

Priyanka Manandhar, Andrea L Szymczak-Workman, Lawrence P Kane. Tim-3 Is Not Required for Establishment of CD8+ T Cell Memory to Lymphocytic Choriomeningitis Virus. Journal of immunology (Baltimore, Md. : 1950). 2024 Feb 01;212(3):466-474