A new role for resveratrol: Protection of enamel against erosion.

Journal of dentistry 2024 Feb

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The aim of this study was to determine the effect of different concentrations of resveratrol in protecting enamel against initial dental erosion in vitro. Ninety bovine enamel samples (4 × 4 mm) were divided into six groups: Phosphate buffered saline (negative control; PBS), Commercial solution (Elmex Erosion Protection™; positive control) and resveratrol at 4 different concentrations (1, 10, 100 or 400 µg/mL). Initially, the samples were incubated in saliva for the formation of the acquired pellicle (250 µL, 1 h, 37 °C, 250 rpm). Afterward, the samples were incubated in the respective treatments (250 µL, 1 min, 37 °C, 250 rpm) and then reincubated in saliva (250 µL, 1 h, 37 °C, 250 rpm). Finally, the samples were subjected to an erosive challenge by incubating in 1 % citric acid (1 mL, pH 3.5, 1 min, 25 °C, 250 rpm). The percentage surface microhardness change (% SMC) was assessed using a microhardness tester. Data were analyzed by Kruskal-Wallis and Dunn's tests (p < 0.05). The treatments with Elmex™ and resveratrol (1, 10 and 100 µg/mL) significantly protected enamel compared to the negative control, without significant differences among them. However, the group treated with the highest resveratrol concentration (400 µg/mL) did not show a significant difference from the negative control. Resveratrol at concentrations ranging from 1 to 100 µg/ml was effective in preventing loss of enamel surface microhardness. This result suggests a potential new direction for the development of dental products based on resveratrol for the prevention of dental erosion. Copyright © 2023. Published by Elsevier Ltd.

Citation

Fernanda Navas Reis, Vinicius Taioqui Pelá, João Victor Frazão Câmara, Talita Mendes Oliveira Ventura, Chelsea Maria Vilas Boas Feitosa Rodrigues, Karen Pavan de Lima, Marília Afonso Rabelo Buzalaf. A new role for resveratrol: Protection of enamel against erosion. Journal of dentistry. 2024 Feb;141:104810