Management of aggressive variants of papillary thyroid cancer.

Ying Ki Lee, Aleix Rovira, Paul V Carroll, Ricard Simo

Current opinion in otolaryngology & head and neck surgery 2024 Apr 01

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The aim of this study was to provide a timely and relevant review of the latest findings and explore appropriate management of aggressive variants of papillary thyroid cancer (AVPTC). In general, AVPTCs tend to exhibit more invasive characteristics, a lack of responsiveness to radioiodine, increased occurrences of regional spreading, distant metastases and higher mortality rates. Meanwhile, each variant showcases unique clinical and molecular profiles. Given the elevated risk of recurrence postsurgery, a more aggressive strategy may be necessary when suspected preoperatively, particularly for those presenting with invasive features. Decision on the extent of surgical treatment and adjuvant therapy is individualized and made by experienced clinicians and multidisciplinary teams based on the clinical presentation, presence of aggressive features and molecular profile. Future studies on development of personalized medicine and molecular target therapy may offer tailored treatment options. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Ying Ki Lee, Aleix Rovira, Paul V Carroll, Ricard Simo. Management of aggressive variants of papillary thyroid cancer. Current opinion in otolaryngology & head and neck surgery. 2024 Apr 01;32(2):125-133