Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital.

Liver international : official journal of the International Association for the Study of the Liver 2024 Feb

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Drug-induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion of DILI from 2018 to 2023. A total of 106 patients fulfilled the diagnostic criteria (30 caused by paracetamol were excluded; total number 76). The pattern of liver injury was hepatocellular in 55 (72%). Drugs causing DILI were antineoplastic (26%), antibiotics (24%), analgesics (12%), and recreational drugs (9%). Regarding clinical outcomes, 39 (51%) required hospitalization and 7 (9%) underwent a liver transplantation or died from acute liver injury. We identified 126 additional patients with DILI due to immune check-point inhibitors who were not referred to a liver disease specialist. Antineoplastic drugs have become the first cause of DILI in hospitals. A multidisciplinary approach and specific educational tools to increase DILI awareness are needed among different specialists. © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Citation

Anna Pocurull, Maria José Moreta, David Heitman, Ignasi Olivas, Cristina Collazos, Elia Canga, Joaquin Sáez-Peñataro, Raul J Andrade, M Isabel Lucena, Zoe Mariño, Alba Díaz, Sabela Lens, María Carlota Londoño, Xavier Forns. Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital. Liver international : official journal of the International Association for the Study of the Liver. 2024 Feb;44(2):286-292