Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

Studies of the interactions between paracetamol, chosen as model active ingredient, and PEG 1500, a pharmaceutical carrier, are conducted in the solid state. Solid dispersions of PEG 1500 and paracetamol were prepared in different mass ratios. Two temperature cycles are then applied and the characterization is carried out by DSC and X-ray powder diffraction. Following this, a phase diagram is established for each cycle. On second heating, the metastable Form II of paracetamol is obtained within the PEG-based matrix. However, on the second heating, for paracetamol contents higher than 65%, Form I or form II is obtained randomly. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Maïlys Rassat, Ingrid Ouandji, Nicolas Guiblin, Philippe Espeau. Obtaining two polymorphic forms of paracetamol within the phase diagram with PEG 1500. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 Feb;195:114173

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 38145856

View Full Text