Treatment of REM sleep behavior disorder with trazodone: report of 3 cases.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2024 May 01

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Rapid eye movement sleep behavior disorder is a sleep disturbance characterized by the absence of regular paralysis during rapid eye movement sleep, accompanied by dream enactment behavior. The available pharmacotherapy options for treating rapid eye movement sleep behavior disorder are limited, and the utilization of antidepressants has yielded mixed results. We report 3 cases of isolated rapid eye movement sleep behavior disorder improved with trazodone. Doses of 50-100 mg of trazodone at bedtime over 4-6 months resulted in significant clinical improvement. These cases highlight that trazodone could serve as a treatment for isolated rapid eye movement sleep behavior disorder that does not respond to traditional treatments at submaximal dosages. Barrow J, Vendrame M. Treatment of REM sleep behavior disorder with trazodone: report of 3 cases. J Clin Sleep Med. 2024;20(5):821-823. © 2024 American Academy of Sleep Medicine.

Citation

Jorden Barrow, Martina Vendrame. Treatment of REM sleep behavior disorder with trazodone: report of 3 cases. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 2024 May 01;20(5):821-823