Chun-Yang Zhang, Jiao-Zhen Zhang, Yue-Lan Li, Ze-Jun Xu, Ya-Nan Qiao, Shuang-Zhi Yuan, Ya-Jie Tang, Hong-Xiang Lou
Journal of natural products 2024 Jan 26Mylnudones A-G (1-7), unprecedented 1,10-seco-aromadendrane-benzoquinone-type heterodimers, and a highly rearranged aromadendrane-type sesquiterpenoid (8), along with four known analogs (9-12), were isolated from the liverwort Mylia nuda. Compounds 1-6 and 7, bearing tricyclo[6.2.1.02,7] undecane and tricyclo[5.3.1.02,6] undecane backbones, likely formed via a Diels-Alder reaction and radical cyclization, respectively. Their structures were determined by spectroscopic analysis, computational calculation, and single-crystal X-ray diffraction analysis. Dimeric compounds displayed cytoprotective effects against glutamic acid-induced neurological deficits.
Chun-Yang Zhang, Jiao-Zhen Zhang, Yue-Lan Li, Ze-Jun Xu, Ya-Nan Qiao, Shuang-Zhi Yuan, Ya-Jie Tang, Hong-Xiang Lou. Heterodimers of Aromadendrane Sesquiterpenoid with Benzoquinone from the Chinese Liverwort Mylia nuda. Journal of natural products. 2024 Jan 26;87(1):132-140
PMID: 38157445
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