Hydroxyurea reduces infections in children with sickle cell anemia in Uganda.

After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001). © 2024 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

Citation

Ruth Namazzi, Caitlin Bond, Andrea L Conroy, Dibyadyuti Datta, Abner Tagoola, Michael J Goings, Jeong Hoon Jang, Russell E Ware, Robert Opoka, Chandy C John. Hydroxyurea reduces infections in children with sickle cell anemia in Uganda. Blood. 2024 Apr 04;143(14):1425-1428

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PMID: 38169476

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