Endometriosis and microbiom].

Endometriosis is a multifactorial disease, hence the difficulty to explain its cause with a single factor. Since the causes of endometriosis are not clear, it is difficult to screen and treat the disease. Currently, the most common treatment methods for endometriosis are hormonal drugs – such as GnRH agonist injections, progestogen implants – and surgical removal of the affected tissue or reduction of its size. Currently, there is no reliable non-invasive method to confirm endometriosis without surgery, and many patients feel that hormone therapy and surgery are ineffective in preventing recurrence. Based partly on our own results and partly on the basis of extensive literature, our research group concluded that the microbiome of the lower and upper female genital tract and the gut play a role in the development of endometriosis. A more detailed mapping of the bacterial community of the mentioned areas can be an important step towards a better understanding of the pathomechanism of endometriosis and provide additional new diagnostic methods for the clinician. Future prospective studies with larger samples and a more rigorous methodology combined with standardization of patients are needed to clarify the role of the microbiome in the pathogenesis and clinical features of endometriosis and to clarify the effect of possible interventions. Orv Hetil. 2024; 165(1): 3–13.

Citation

Vilmos Fülöp, Kornél Lakatos, György Végh, László Kalmár, Éva Pállinger. Endometriosis and microbiom]. Orvosi hetilap. 2024 Jan 07;165(1):3-13

Mesh Tags

PMID: 38189832

search → result