Visible-Light-Mediated Bimetal-Catalyzed meta-Alkylation of Arenes.

A mild approach to the visible-light-mediated bimetal-catalyzed meta-alkylation of arenes has been accomplished. The regioselective meta-alkylation is realized by a bimetallic ruthenium-palladium system. Ruthenium acts as a catalyst for the directing effect and as a photosensitizer, while the cocatalyst palladium behaves as a catalyst for the generation of fluoroalkyl radicals. This reaction not only is suitable for two-component meta-fluoroalkylation of arenes but can also be extended to three-component reactions to achieve bifunctionalization of olefins.

Citation

Peng-Cheng Cui, Guan-Wu Wang. Visible-Light-Mediated Bimetal-Catalyzed meta-Alkylation of Arenes. Organic letters. 2024 Jan 19;26(2):427-432

PMID: 38190630

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