Unlocking translational machinery for antitubercular drug development.

Navneet Kumar, Mushtaq Ahmad Wani, Chaaya Iyengar Raje, Prabha Garg

Trends in biochemical sciences 2024 Mar

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Targeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of Mycobacterium tuberculosis (Mtb) elongation factor thermo unstable-GDP (EF-Tu-GDP), elongation factor thermo stable-EF-Tu (EF-Ts-EF-Tu), and elongation factor G-GDP (EF-G-GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Navneet Kumar, Mushtaq Ahmad Wani, Chaaya Iyengar Raje, Prabha Garg. Unlocking translational machinery for antitubercular drug development. Trends in biochemical sciences. 2024 Mar;49(3):195-198