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How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains. Copyright © 2023 Elsevier Inc. All rights reserved.
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Qingyun Li. TIMely connections: APOE4, aging, and Alzheimer's. Immunity. 2024 Jan 09;57(1):8-10
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PMID: 38198855
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