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    Iridium(III) complexes are emerging as a promising tool in the area of detection and therapy due to their prominent photophysical properties, including higher photostability, tunable phosphorescence emission, long-lasting phosphorescence, and high quantum yields. In recent years, much effort has been devoted to develop novel near-infrared (NIR) iridium(III) complexes to improve signal-to-noise ratio and enhance tissue penetration. In this review, we summarize different classes of organometallic NIR iridium(III) complexes for detection and therapy, including cyclometalated ligand-enabled NIR iridium(III) complexes and NIR-dye-conjugated iridium(III) complexes. Moreover, the prospects and challenges for organometallic NIR iridium(III) complexes for targeted detection and therapy are discussed.

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    Shaozhen Jing, Xiaolei Wu, Dou Niu, Jing Wang, Chung-Hang Leung, Wanhe Wang. Recent Advances in Organometallic NIR Iridium(III) Complexes for Detection and Therapy. Molecules (Basel, Switzerland). 2024 Jan 03;29(1)

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    PMID: 38202839

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