The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke.

Stroke is a prevalent cerebrovascular condition with a global impact, causing significant rates of illness and death. Despite extensive research, the available treatment options for stroke remain restricted. Hence, it is crucial to gain a deeper understanding of the molecular mechanisms associated with the onset and advancement of stroke in order to establish a theoretical foundation for novel preventive and therapeutic approaches. NF-κB, also known as nuclear factor κB, is a transcription factor responsible for controlling the expression of numerous genes and plays a crucial role in diverse physiological processes. NF-κB is triggered and regulates neuroinflammation and other processes after stroke, promoting the generation of cytokine storms and contributing to the advancement of ischemic stroke (IS). Therefore, NF-κB could potentially play a vital role in stroke by regulating diverse pathophysiological processes. This review provides an overview of the functions of NF-κB in stroke and its governing mechanisms. In addition, our attention is directed towards various potential therapies that aim to inhibit the NF-κB signaling pathway in order to offer valuable insights for the advancement of innovative treatment approaches for stroke. Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Citation

Guangyu Xu, Fang Dong, Lei Su, Zi-Xuan Tan, Mingcheng Lei, Lina Li, Di Wen, Feng Zhang. The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Feb;171:116140

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PMID: 38211425

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