Signalling of Adrenoceptors: Canonical Pathways and New Paradigms.

The concept of G protein-coupled receptors initially arose from studies of the β-adrenoceptor, adenylyl cyclase, and cAMP signalling pathway. Since then both canonical G protein-coupled receptor signalling pathways and emerging paradigms in receptor signalling have been defined by experiments focused on adrenoceptors. Here, we discuss the evidence for G protein coupling specificity of the nine adrenoceptor subtypes. We summarise the ability of each of the adrenoceptors to activate proximal signalling mediators including cAMP, calcium, mitogen-activated protein kinases, and protein kinase C pathways. Finally, we highlight the importance of precise spatial and temporal control of adrenoceptor signalling that is controlled by the localisation of receptors at intracellular membranes and in larger protein complexes. © 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.

Citation

Chantel Mastos, Xiaomeng Xu, Alastair C Keen, Michelle L Halls. Signalling of Adrenoceptors: Canonical Pathways and New Paradigms. Handbook of experimental pharmacology. 2024 Jan 17

PMID: 38227198

search → result