Roberta Bovenzi, Mariangela Pierantozzi, Matteo Conti, Silvia Carignani, Mariana Fernandes, Tommaso Schirinzi, Rocco Cerroni, Nicola Biagio Mercuri, Alessandro Stefani, Claudio Liguori
Journal of neural transmission (Vienna, Austria : 1996) 2024 MarREM sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson's disease (PD), and the timing of its presentation might have a role in the underlying neurodegenerative process. Here, we aimed to define the potential impact of probable RBD (pRBD) on PD motor progression.We conducted a longitudinal retrospective study on 66 PD patients followed up at the University Hospital of Rome Tor Vergata. Patients were divided into three groups: with post-motor pRBD (pRBDpost, n = 25), without pRBD (pRBDwo, n = 20), and with pre-motor pRBD (pRBDpre, n = 21). Hoehn and Yahr (H&Y) scores, Unified PD Rating Scale (UPDRS) motor scores, and levodopa equivalent daily dose were collected at two follow-up visits conducted in a 5-year interval (T0 and T1). pRBDpost patients had a greater rate of motor progression in terms of the H&Y scale compared to pRBDpre and pRBDwo patients, without the influence of anti-parkinsonian treatment.These preliminary findings suggest that the post-motor occurrence of pRBD can be associated with an acceleration in PD motor progression. © 2024. The Author(s).
Roberta Bovenzi, Mariangela Pierantozzi, Matteo Conti, Silvia Carignani, Mariana Fernandes, Tommaso Schirinzi, Rocco Cerroni, Nicola Biagio Mercuri, Alessandro Stefani, Claudio Liguori. Parkinson's disease motor progression in relation to the timing of REM sleep behavior disorder presentation: an exploratory retrospective study. Journal of neural transmission (Vienna, Austria : 1996). 2024 Mar;131(3):239-244
PMID: 38227218
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