Subcutaneous leiomyosarcoma in a cynomolgus macaque (Macaca fascicularis).

Leiomyosarcoma, a malignant tumour originating from smooth muscle cells, has rarely been documented in non-human primates. In this case study, a 7-year-old female cynomolgus macaque (Macaca fascicularis) presented with a rapidly growing mass overlying the left elbow joint. Radiographs indicated the presence of a soft tissue neoplasm without any associated bone involvement. The mass was surgically resected. Histological and immunohistochemical analyses revealed spindle-shaped cells with eosinophilic cytoplasm that resembled smooth muscle cells, exhibiting positive immunoreactions for vimentin, desmin and smooth muscle actin and a negative reaction for pan-cytokeratin. This is the first reported case of subcutaneous leiomyosarcoma in a cynomolgus macaque and provides important insights into the incidence and characteristics of this condition in this species. © 2024 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.

Citation

Dong-Ho Lee, Jun Won Mo, Seung-Bin Yoon, Jeongwoo Kwon, Yu-Jin Jo, Sang Il Lee, Taeho Kwon, Jungkee Kwon, Ji-Su Kim. Subcutaneous leiomyosarcoma in a cynomolgus macaque (Macaca fascicularis). Veterinary medicine and science. 2024 Jan;10(1):e1321

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PMID: 38227706

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