Folic acid: friend or foe in cancer therapy.

Folic acid plays a crucial role in diverse biological processes, notably cell maturation and proliferation. Here, we performed a literature review using articles listed in electronic databases, such as PubMed, Scopus, MEDLINE, and Google Scholar. In this review article, we describe contradictory data regarding the role of folic acid in cancer development and progression. While some studies have confirmed its beneficial effects in diminishing the risk of various cancers, others have reported a potential carcinogenic effect. The current narrative review elucidates these conflicting data by highlighting the possible molecular mechanisms explaining each point of view. Further multicenter molecular and genetic studies, in addition to human randomized clinical trials, are necessary to provide a more comprehensive understanding of the relationship between folic acid and cancer.

Citation

Romany H Thabet, Raneem Eid Mustafa Alessa, Zahraa Khaldoon Khaleel Al-Smadi, Banah Saleh Gabr Alshatnawi, Batool Mahmoud Ibrahim Amayreh, Renad Bilal Ahmad Al-Dwaaghreh, Sereen Khalid Ahmad Salah. Folic acid: friend or foe in cancer therapy. The Journal of international medical research. 2024 Jan;52(1):3000605231223064

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PMID: 38229460

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