Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling.

Recent advances in cryo-electron microscopy (Cryo-EM) have revolutionized our understanding of the complement C5a/C3a receptors that are crucial in inflammation. A recent report by Yadav et al. has elucidated the activation, ligand binding, selectivity, and signaling bias of these receptors, thereby enhancing structure-guided drug discovery. This paves the way for more effective anti-inflammatory therapies that target these receptors with unprecedented precision. Copyright © 2024 Elsevier Ltd. All rights reserved.

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Francisco J Fernández, M Cristina Vega. Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling. Trends in biochemical sciences. 2024 Apr;49(4):280-282

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PMID: 38233283

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