CDC123 promotes Hepatocellular Carcinoma malignant progression by regulating CDKAL1.

The cell proliferation protein 123 (CDC123) is involved in the synthesis of the eukaryotic initiation factor 2 (eIF2), which regulates eukaryotic translation. Although CDC123 is considered a candidate oncogene in breast cancer, its expression and role in Hepatocellular Carcinoma (HCC) remain unknown. Herein, we obtained the CDC123 RNA-seq and clinical prognostic data from the TCGA database. The mRNA level revealed that CDC123 was highly expressed in HCC patients, and Kaplan-Meier analysis implied better prognoses in HCC patients with low CDC123 expression (P < 0.001). The multivariate Cox analysis revealed that the CDC123 level was an independent prognostic factor (P < 0.001). We further confirmed a high CDC123 expression in HCC cell lines. Additionally, we found that CDC123 knockdown in HCC cell lines significantly inhibited cellular proliferation, invasion, and migration. Moreover, CDC123 was co-expressed with the CDK5 Regulatory Subunit-Associated Protein 1 Like 1 (CDKAL1), whose mRNA level was decreased after silencing CDC123. Therefore, we hypothesized that CDC123 promotes HCC progression by regulating CDKAL1. Copyright © 2024. Published by Elsevier GmbH.

Citation

Yong Wang, HongTao Pan, XuanKun Gong, ZhiCheng Wang, XiLiang Qin, Shuai Zhou, Chao Zhu, XiaoSi Hu, ShiLei Chen, HuiChun Liu, Hao Jin, Qing Pang, WenYong Wu. CDC123 promotes Hepatocellular Carcinoma malignant progression by regulating CDKAL1. Pathology, research and practice. 2024 Feb;254:154987

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PMID: 38237400

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