SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications - review article.

Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore, which plays a vital role in proper chromosomal segregation and cell division. Recently, SKA3 have been demonstrated its oncogenic role of tumorigenesis and development in cancers. In this review, the authors comprehensively deciphered SKA3 in human cancer from various aspects, including bibliometrics, pan-cancer analysis, and narrative summary. The authors also provided the top 10 predicted drugs targeting SKA3. The authors proposed that SKA3 was a potential target and brought new therapeutic opportunities for cancer patients. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

Citation

Dechao Feng, Jie Wang, Yuhan Xiao, Ruicheng Wu, Dengxiong Li, Zhouting Tuo, Qingxin Yu, Luxia Ye, Akira Miyamoto, Koo Han Yoo, Wuran Wei, Xing Ye, Chi Zhang, Ping Han. SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications - review article. International journal of surgery (London, England). 2024 Apr 01;110(4):2323-2337

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PMID: 38241327

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